Nitrazepam has been associated with severe hepatic disorders, comparable to other nitrobenzodiazepines. Nitrobenzodiazepines which include nitrazepam, nimetazepam, flunitrazepam, and clonazepam tend to be more toxic to the liver than other benzodiazepines as They're metabolically activated by CYP3A4 which can lead to cytotoxicity.[30] Warning needs